Control of solvated crystallisation of α-lactose monohydrate

نویسندگان

  • Amira Rachah
  • Dominikus Noll
  • Fabienne Espitalier
  • Fabien Baillon
چکیده

We present a mathematical model of solvated crystallization of α-lactose monohydrate and discuss strategies to control the crystallization process in semi-batch mode with the goal to privilege the production of small particles in the range between 130μm and 330μm. We compare specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed.

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عنوان ژورنال:
  • IJMNO

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2015